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KMID : 0882420080750000930
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Korean Journal of Medicine
2008 Volume.75 No. 0 p.930 ~ p.934
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Clinical improvement of ankylosing spondylitis on switching tumor necrosis factor inhibitors: a case report
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Lee Jae-Gun
Park Hyun-Jin
Lee Yeon-Ah
Hong Seung-Jae
Lee Sang-Hoon
Yang Hyung-In
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Abstract
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Ankylosing spondylitis is a seronegative multi-system inflammatory disorder affecting, primarily, the axial skeleton. Anti-tumor necrosis factor (TNF)-alpha agents promise better disease control for the treatment of ankylosing spondylitis resistant to classical disease-modifying treatment, and provide a better functional outcome. We present the case of a 20-year-old male diagnosed with ankylosing spondylitis. After two years of treatment with infliximab, the patient developed a clinical picture compatible with infliximab failure. We increased the dose of infliximab, but with no effect. Therefore, the infliximab therapy was halted, and the patient was treated with adalimumab. After 4 weeks, his symptoms improved, including his lower back stiffness, multiple arthralgia, and hip flexion contracture, and so did the laboratory findings. Based on this case, we review switching tumor necrosis factor inhibitors in ankylosing spondylitis. (Korean J Med 75:S930-S934, 2008)
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KEYWORD
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Ankylosing spondylitis, Infliximab, Adalimumab
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